منابع مشابه
YopM puts caspase-1 on ice.
Caspase-1-mediated detection of pathogens is a potent arm of the innate immune system. LaRock and Cookson (2012) show that the Yersinia type III secretion effector, YopM, directly inhibits caspase-1.
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YopM is a leucine-rich repeat (LRR)-containing effector in several Yersinia species, including Yersinia pestis and Y. pseudotuberculosis. Different Yersinia strains encode distinct YopM isoforms with variable numbers of LRRs but conserved C-terminal tails. A 15-LRR isoform in Y. pseudotuberculosis YPIII was recently shown to bind and inhibit caspase-1 via a YLTD motif in LRR 10, and attenuation...
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A potato virus makes its move T ilsner et al. describe how three viral proteins combine to help newly synthesized viruses spread to neighboring plant cells. Plant viruses move between cells through narrow channels in the cell wall called plasmodesmata. Potato virus X, which replicates on the surface of the endoplasmic reticulum (ER), encodes three proteins—TGB1, 2, and 3—that promote the virus'...
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Under conditions of limited nutrients, eukaryotic cells reprogram protein expression in a way that slows growth but enhances survival. Recent data implicate stress granules, discrete cytoplasmic foci into which untranslated mRNPs are assembled during stress, in this process. In the October 1, 2011, issue of Genes & Development, Damgaard and Lykke-Andersen (p. 2057-2068) provide mechanistic insi...
متن کاملIncreased serum concentrations of soluble CD95/Fas and caspase 1/ICE in patients with acute angina.
OBJECTIVES To investigate the expression of death inducing receptors in the sera of patients with stable and unstable angina. DESIGN 80 consecutive patients with stable (n = 40) or unstable (n = 40) angina pectoris were studied. Serum concentrations of soluble CD95 (sCD95), soluble CD95 ligand (sCD95L; CD178), tumour necrosis factor (TNF) alpha, soluble TNFalpha receptor type 1 (sTNFR1), and ...
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ژورنال
عنوان ژورنال: Cell Host & Microbe
سال: 2012
ISSN: 1931-3128
DOI: 10.1016/j.chom.2012.11.006